Glucosamine

There have been numerous studies that show people with mild to moderate osteoarthritis taking glucosamine reported pain relief at a level similar to that of nonsteroidal anti-inflammatory drugs (NSAIDs). Additional research also indicates that glucosamine along with other supplements like chondroitin may also slow cartilage damage in people with osteoarthritis. Because of this research and positive feedback from people taking it, oral glucosamine is commonly used for the treatment of osteoarthritis.

Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness.[6][7] A randomized, double-blind, placebo-controlled trial found glucosamine sulfate is no better than placebo in reducing the symptoms or progression of hip osteoarthritis. [8]

A typical dosage of glucosamine salt is 1,500 mg per day. Glucosamine contains an amino group that is positively charged at physiological pH. The anion included in the salt may vary. Commonly sold forms of glucosamine are glucosamine sulphate and glucosamine hydrochloride. The amount of glucosamine present in 1500 mg of glucosamine salt will depend on which anion is present and whether additional salts are included in the manufacturer's calculation.[9] Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane.

Glucosamine is a popular alternative medicine used by consumers for the treatment of osteoarthritis. Glucosamine is also extensively used in veterinary medicine as an unregulated but widely accepted supplement.[10]

Resource: Portions from Wikipedia contributors, 'Glucosamine', Wikipedia, The Free Encyclopedia, 2 July 2008, 16:03 UTC, <http://en.wikipedia.org/w/index.php?title=Glucosamine&oldid=223101529> [accessed 15 July 2008]